Trauma and lipid-peroxidation / cytokine series
In patients with open long-bone fractures, combination-therapy papers describe vilon stabilising lipid-peroxidation / antioxidant readouts and normalising selected cytokines.
identity
sequence
Lys · Glu
Key takeaways
- Vilon is the Lys-Glu dipeptide in the same St. Petersburg bioregulator shop as thymogen. A defined thymic-series fragment. Separate from extract products.
- Mapped themes include trauma / lipid-peroxidation series, comparative surgical immunity papers with thymalin and epithalamin, PBMC TNFα work, and cartilage explant culture.
- Trauma and appendicitis material is largely same-school Russian case series; an unrelated multi-layer network method named ViLoN was dropped from the PubMed retrieval.
What it is
Vilon is the Lys-Glu dipeptide in the same St. Petersburg bioregulator shop as thymogen. another defined thymic-series fragment, sold in Russia as a dietary supplement framed around senescence biology.
Unlike thymalin (an extract), vilon is a single sequence; unlike thymogen (Glu-Trp), the amino acids differ and the mapped effects are not identical.
We feature it because trauma and immunity series give a readable paper trail on the St. Petersburg shelf.
What the literature describes
Themed chapters drawn only from papers already mapped on this dossier. Archive map. No medical advice.
Comparative surgical immunity series
Comparative surgical series (complicated appendicitis) discuss thymalin, epithalamin, or vilon in the same immunity-and-wound-healing frame.
PBMC TNFα synthesis work
Human PBMC work reports vilon accelerating TNFα synthesis. a finding the archive flags as mechanistically open.
Cartilage explant culture
Cartilage explant culture papers describe effects on cell proliferation in young-donor organotypic models (one finding; older axis dump repeated this three ways).
Research trail
Trauma and appendicitis material is largely same-school Russian case series; cellular immunology papers sit nearby. Conceptual “regulatory peptides and homeostasis” reviews from the Khavinson circle frame the programme.
That St. Petersburg shelf is where the densest mapped trail lives.
Open limits
- What distinguishes Lys-Glu (vilon) from Glu-Trp (thymogen) at the mechanism level in the mapped papers?
- Is vilon an active principle inside thymalin, or a parallel tool?
- How should TNFα upregulation be read for an “immunomodulator” label in the literature?
Russian full-text papers
- molekulyarno dinamicheskoe modelirovanie lizinovyh dendrimerov i ih gibridov s bioaktiv Russian full text
- patogeneticheskoe obosnovanie ispolzovaniya vilona v profilaktike posleoperatsionnyh gn Russian full text
- sravnitelnoe deystvie timalina epitalamina i vilona na sostoyanie immuniteta u bolnyh s Russian full text
- regulyatornye peptidy i gomeostaz Russian full text
- opyt klinicheskogo primeneniya timomimetika vilona v lechenii diffuznogo toksicheskogo Russian full text
- neyroprotektornye svoystva neyropeptidov Russian full text
- kompleksnaya terapiya hronicheskogo parodontita u pozhilyh Russian full text
- bioreguliruyuschaya terapiya hronicheskogo paraproktita Russian full text
8 curated · off-topic curriculum / food-tech rows removed
Also on PubMed
- 2020 [The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.]. PubMed
- 2020 [Age features of bioregulatory therapy of dental diseases.]. PubMed
- 2017 [Effect of combined application of ozone therapy and gravitational therapy on the remote results of complex treatment of geriatric patients]. PubMed
- 2015 Comparison of treatment options for experimental endometriosis in rats. doi:10.1007/s10517-015-2834-8 PubMed
- 2013 Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells. doi:10.1007/s10517-013-2000-0 PubMed
- 2013 [Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results]. PubMed
- 2013 [Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)]. PubMed
- 2012 Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture. doi:10.1007/s10517-012-1689-5 PubMed
- 2008 Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments. doi:10.1007/s11055-008-0035-x PubMed
9 curated · unrelated ViLoN network-method hit removed
Still open
- What distinguishes Lys-Glu (vilon) from Glu-Trp (thymogen) at the mechanism level?
- Is vilon an active principle inside thymalin, or a parallel tool?
- Is wound-healing promotion direct on fibroblasts or via immune modulation?
- How should TNFα upregulation be read for an “immunomodulator” label in the literature?
Reviewed against the archive corpora on 2026-09-19. Source-grounded. No clinical claims. Archive / history / research only. No medical advice. No dosing, synthesis, sourcing, or health claims.