Polypeptide fraction from mammalian retina, registered in Russia for retinal dystrophies and post-surgical retinal recovery. The dossier includes a specific Soviet-era military application claim. improvement after laser-weapon retinal damage. preserved here as part of the Russian military-ophthalmology shelf.
mechanism confidence: medium
Polypeptide fraction from bovine retina (Kirov Military Medical Academy). Three documented mechanism domains:
- cataract-stasis. 57 patients with post-inflammatory chorioretinal degeneration, retinalamin in combination therapy slows maturation of complicated cataract and prevents vision loss (Alexandrova 2008)
- retinal neuroprotection. molecular mechanism shared with epithalon is stimulation of neuronal and pigment-epithelium differentiation (Linkova 2013)
- circadian rhythm restoration. primary open-angle glaucoma patients, retinalamin restores disrupted circadian rhythms of IOP, BP, HR (Malishevskaya 2016)
- neuronal marker normalisation. 23 patients (46 eyes) primary open-angle glaucoma, retinalamin normalises neurotrophic/neurodegeneration balance in tear fluid (Gabdrakhmanova 2018). The Khavinson 2020 master review frames retinalamin as part of the original Military Medical Academy organ-specific peptide family.
- 57 patients post-inflammatory chorioretinal degeneration + complicated cataract: retinalamin in combination slows cataract maturation, prevents vision loss (Alexandrova 2008)
- Molecular mechanism: retinalamin + epithalon stimulate neuronal and pigment-epithelium differentiation (Linkova 2013)
- 23 patients (46 eyes) primary open-angle glaucoma: retinalamin normalises neurotrophic/neurodegeneration markers in tear fluid (Gabdrakhmanova 2018)
- Primary open-angle glaucoma patients: retinalamin restores disrupted circadian rhythms of IOP, BP, HR (Malishevskaya 2016)
- Khavinson 2020 master review: retinalamin is original Kirov Military Medical Academy organ-specific peptide, developed for retinal function restoration after laser-weapon exposure (per Khavinson original programme)
grade: Moderate. Multiple direct clinical case series (57 patients chorioretinal, 46 eyes glaucoma, 23 patients glaucoma) but no multi-centre programmes beyond the mapped Russian/CIS series appear in our archive. The original laser-weapon exposure indication (Khavinson 2020) is unique historical context.
- Cataract-stasis mechanism. direct lens protein protection or anti-inflammatory?
- Circadian rhythm restoration in glaucoma. is this via pineal axis or direct retinal effect?
- Tear fluid biomarker normalisation. does this correlate with functional visual outcomes?
- Original laser-weapon exposure indication. has this been published in classified Russian military medicine?
- PMID 395697812024[Objective structural and functional monitoring of polypeptide retinal neuroprotective therapy in diabetic retinopathy]. doi:10.17116/oftalma202414005197Vestnik oftalmologii
- PMID 347268592021[Retinoprotective effects of Retinalamin studied in an experimental model of photochemical damage to rabbit retinas]. doi:10.17116/oftalma202113705157Vestnik oftalmologii
- PMID 323660712020[Peptide bioregulators: delivery and efficacy]. doi:10.17116/oftalma202013602156Vestnik oftalmologii
- PMID 240037262013[Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results].Advances in gerontology = Uspekhi gerontologii
- PMID 115214262001[Effectiveness of bio-regulators in the treatment of diabetic retinopathy].Vestnik oftalmologii
- PMID 129376842003Effects of peptides on proliferative activity of retinal and pigmented epithelial cells. doi:10.1023/a:1025497806636Bulletin of experimental biology and medicine
- PMID 128024582002Inductive activity of retinal peptides. doi:10.1023/a:1022654717358Bulletin of experimental biology and medicine
7 total in corpus
Reviewed against the archive corpora on 2026-09-16. Source-grounded. No clinical claims. Synthesis prose may preserve published experimental context from papers; that is research history, not a recommendation.