Polypeptide fraction from bovine prostate, registered in Russia for chronic prostatitis and post-surgical recovery. One of the earliest Khavinson cytomedins to be commercialized and the one with the most consistent Russian clinical use.
mechanism confidence: medium
Polypeptide fraction from bovine prostate (Cytomed production). Mechanism combines anti-inflammatory and tissue-specific regenerative effects:
- chronic abacterial prostatitis treatment. 35 men (mean age 31.3±4.3y) with elevated sperm DNA fragmentation, Prostatilen® AC reduces DNA fragmentation, improves reproductive function at 1, 2, 3 months post-treatment (Borovets-Rybalov-Gorbachev-Al-Shukri-Levina 2018)
- acute cystitis. experimental 60 female rats with chemical cystitis (dimexide+o-xylene 3:1 bladder instillation), prostatilen suppositories effective (Al-Shukri-Gorbachev-Borovets 2009)
- chronic prostatitis pathogenetic study. 82 Wistar male rats, prostatilen effective in prophylaxis (Gorbachev-Borovets-Rybalov-Tyurin 2020)
- combination peptide therapy for male infertility. review covering Prostatilen + other peptides for urogenital infection-related infertility (Prokopiev-Abdrahmanov 2021). The mechanism is likely tissue-specific regenerative + anti-inflammatory. peptide bioregulator paradigm.
- 35 men (mean age 31.3y) chronic abacterial prostatitis + elevated sperm DNA fragmentation: Prostatilen® AC treatment reduces DNA fragmentation at 1/2/3 months post-treatment (Borovets 2018)
- 60 female rats chemical cystitis (dimexide+o-xylene 3:1 bladder instillation ×3 min): prostatilen suppositories effective (Al-Shukri 2009)
- 82 Wistar male rats chronic prostatitis model: prostatilen prophylaxis effective (Gorbachev 2020)
- Adjacent: combined peptide drugs (Prostatilen + others) for male urogenital-infection infertility. literature review (Prokopiev-Abdrahmanov 2021)
- Acute/chronic prostatitis peptide treatment in experiment. Gorbachev-Tyurin 2015
grade: Moderate-strong for the chronic abacterial prostatitis indication. Multiple direct studies with consistent findings. Clinical RCTs not international (Al-Shukri is at St. Petersburg Pavlov State Medical University).
- Mechanism at the molecular level. peptide-receptor identification?
- Comparison with tadalafil / 5α-reductase inhibitors head-to-head?
- Why does a prostate extract reduce sperm DNA fragmentation. direct DNA protection or systemic anti-inflammatory?
- Long-term outcomes. pregnancy rates, live birth rates post-treatment?
- PMID 424173032026[Effect of prostate-derived complex peptide preparations on erectile function in patients with chronic prostatitis].Urologiia (Moscow, Russia : 1999)
- PMID 263906192015[POLYPEPTIDES INFLUENCE ON TISSUE CELL CULTURES REGENERATION OF VARIOUS AGE RATS].Advances in gerontology = Uspekhi gerontologii
- PMID 240037262013[Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results].Advances in gerontology = Uspekhi gerontologii
- PMID 18236831991[The use of prostatilen in treating patients with prostatic diseases].Urologiia i nefrologiia
- PMID 83300801993[The effect of prostatic peptides on the contractile activity of smooth-muscle cells from the bladder].Fiziologicheskii zhurnal imeni I.M. Sechenova
5 total in corpus
Reviewed against the archive corpora on 2026-09-16. Source-grounded. No clinical claims. Synthesis prose may preserve published experimental context from papers; that is research history, not a recommendation.