Pineamine bioregulator peptide (Khavinson school). Limited primary literature; full source PDFs preserved in the dossier.
mechanism confidence: medium
The registered drug form of pinealon (tripeptide EDR) for climacteric syndrome. Documented clinical efficacy: Pineamine® vs placebo in multicentre double-blind RCT (Prilepskaya 2016) for neuro-vegetative and psycho-emotional manifestations of menopausal syndrome. Adjacent clinical observations: COVID-19-induced primary hypogonadism treated successfully with Pineamine (Yakovlev 2023). Other adjacent peptide IPH LGA shows protective properties against age-related androgen deficiency (Pochitaeva 2023). Pineamine shares molecular mechanism with pinealon. SOD1/GPX4/GSR gene regulation in hippocampus, prefrontal cortex cognitive rehabilitation. Epiphyseal peptide mesotherapy for skin moisture/elasticity (Korolkova 2017). broader pineal-peptide dermatological use.
- Multicentre double-blind placebo-controlled RCT: Pineamine® for climacteric syndrome. neurovegetative and psychoemotional improvement (Prilepskaya-Bogatova-Radzinsky 2016)
- Clinical observation: COVID-19-induced primary hypogonadism successfully treated with pineamine (Yakovlev-Neimark-Davidov 2023)
- Adjacent: IPH LGA peptide protects against age-related androgen deficiency in animal model (Pochitaeva-Ryzhkova-Krokhmaleva-Fomchenkova-Nurpeisova 2023)
- Adjacent: IPH PRO peptide protects against benign prostatic hyperplasia (Ryzhkova 2023)
- Cosmetic application: epiphyseal peptide mesotherapy improves skin moisture and elasticity (Korolkova-Goma 2017, n=38 women)
grade: No linked papers (0 A / 0 B / 0 C). Climacteric RCT is cited, not in this corpus; other uses are observations.
- Is pineamine just pinealon with a different name, or a different sequence?
- Hypogonadism post-COVID mechanism: direct gonadal protection vs central (pineal axis) restoration
- Cosmetic use of epiphyseal peptides. independent replication outside the Korolkova lab
- Long-term safety in chronic climacteric use (multi-year dosing)
no PubMed-indexed literature in the corpus.
Reviewed against the archive corpora on 2026-09-16. Source-grounded. No clinical claims. Synthesis prose may preserve published experimental context from papers; that is research history, not a recommendation.