Actoprotective treadmill and load work
Rat treadmill-to-exhaustion work after multi-week pinealon reports actoprotective effects discussed as comparable to metaprot in the same experimental conversation.
identity
sequence
Glu · Asp · Arg
Key takeaways
- Pinealon is the Glu-Asp-Arg tripeptide on the Khavinson bioregulator shelf. Russian literature discusses it with a nootropic framing.
- Mapped themes include actoprotective treadmill work, rhesus cognitive aging papers, oxidative-stress correction with cortexin in diabetes models, and athlete reserve-capacity reports.
- Pineamine® climacteric titles in the wider corpus are adjacent product literature. Kept distinct from the research-peptide trail on this page.
What it is
Pinealon is the Glu-Asp-Arg tripeptide on the Khavinson bioregulator shelf. Marketed in Russia with a nootropic framing.
Among Khavinson compounds in our map, its actoprotective, cognitive, and free-radical experimental threads line up with each other across papers.
We feature it because that internal consistency makes a clear narrative across actoprotective, cognitive, and free-radical experimental threads.
What the literature describes
Themed chapters drawn only from papers already mapped on this dossier. Archive map. No medical advice.
Primate cognitive aging papers
Rhesus monkey (Macaca mulatta) papers describe pinealon in rehabilitation of age-related cognitive functions during aging.
Oxidative-stress correction with cortexin
Papers on pinealon with cortexin describe correction of oxidative-stress readouts in blood from diabetes models (model-system work).
Athlete reserve-capacity reports
High-performance athlete papers report pinealon associated with increased reserve capacity of the organism (literature report). Related climacteric titles in the corpus sometimes use Pineamine®. keep that name distinct from the research peptide.
Research trail
Actoprotective and primate cognitive papers are mostly same-school or closely adjacent St. Petersburg work; gene-expression diabetes work adds mechanistic texture in the same ecology.
Pineamine® RCT material is a related product name. Treat it as adjacent product literature. It does not auto-transfer as evidence for the research peptide alone.
Open limits
- Are actoprotective and cognitive effects the same mechanism or parallel ones?
- Has the rhesus cognition result been extended beyond the originating circle’s protocols?
- How exactly do Pineamine® and pinealon relate in registry versus peptide-sequence language?
Russian full-text papers
- issledovanie aktoprotektornyh svoystv tripeptida pinealona Russian full text
- vliyanie pinealona na rezervnye vozmozhnosti organizma vysokokvalifitsirovannyh sportsm Russian full text
- vliyanie tripeptida pinealona na reabilitatsiyu kognitivnyh funktsiy v protsesse staren Russian full text
- primenenie pinealona i korteksina dlya korrektsii okislitelnogo stressa v krovi bolnyh Russian full text
- vliyanie peptidnyh bioregulyatorov na svobodnoradikalnye protsessy i uroven ekspressii Russian full text
5 curated · Pineamine® / climacteric-adjacent rows kept off this peptide page
Also on PubMed
- 2016 [Comparative analysis of different methods of geroprotective]. PubMed
- 2015 [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]. PubMed
- 2015 [Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia]. PubMed
- 2014 [Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon]. PubMed
- 2013 [Effect of peptide geroprotectors on the navigation system learning and caspase-3 in brain structures in rats of different age]. PubMed
- 2013 [Neuroprotective effects of peptides bioregulators in people of various age]. PubMed
- 2012 Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. PubMed
- 2012 [The peptide correction of neurotic disorders among professional truck-drivers]. PubMed
- 2011 [Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats]. PubMed
9 curated · off-topic orthopaedics-peptide review removed
Still open
- Are actoprotective and cognitive effects the same mechanism or parallel ones?
- Has the rhesus cognition result been replicated outside the originating circle?
- How exactly do Pineamine® and pinealon relate in registry versus peptide-sequence language?
- What is the dose-response shape of HbA1c-linked antioxidant findings in diabetes models?
Reviewed against the archive corpora on 2026-09-19. Source-grounded. No clinical claims. Archive / history / research only. No medical advice. No dosing, synthesis, sourcing, or health claims.