A four-amino-acid peptide (Lys-Glu-Asp-Gly) sold in Russia as a hepatoprotective. Thin PubMed footprint; the CyberLeninka record is the deeper source.
mechanism confidence: very low
Synthetic tetrapeptide KEDG (Lys-Glu-Asp-Gly). Not a bovine-liver extract. The mechanism claim is liver-tissue-specific regenerative. but no DIRECT studies on Livagen® product were found in the CyberLeninka audit. Most adjacent literature covers hepatocyte circahourly protein metabolism rhythms (Feldman 2011), immune regulation, infectious immunology, elderly ophthalmology care. The Khavinson-school liver peptide concept is real but lacks dedicated primary literature. This is a research gap, not a confirmed null finding.
- Adjacent: circahourly protein metabolism rhythms in hepatocytes (Feldman-Rozhkova 2011)
- Adjacent: immune regulation, infectious immunology (textbook references 2001, 2003)
- Adjacent: Roncoleukin + colostral immunity in newborn calves. bovine peptide bioregulation paradigm (Russian agricultural literature)
- Adjacent: Drosophila peptide study (Mylnikov 2008). genotype × peptide interaction in longevity
- No DIRECT Livagen® product studies identified in CyberLeninka audit
grade: Very low. No direct primary literature. The compound exists in the Khavinson peptide family but is under-researched.
- Is there any dedicated pharmacology for Livagen® as a drug?
- Liver-tissue-specific regeneration. what would be the analogous model to prostatilen/prostate?
- Comparison with hepatoprotectors (e.g. ademethionine, UDCA). has this been done?
- PMID 323620992020[The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.].Advances in gerontology = Uspekhi gerontologii
- PMID 285743952017[EVALUATION OF GENOMIC PARAMETERS IN DUCTAL BREAST CANCER PATIENTS AND THE ABILITY OF IT'S CORRECTION].Georgian medical news
- PMID 255418322014[Genomic instability in atherosclerosis].Georgian medical news
- PMID 253412542014[Effect of peptide bioregulator and cobalt ions on the activity of NORs and associations of acrocentric chromosomes in lymphocytes of patients with hypertrophic cardiomyopathy and their relatives].Georgian medical news
- PMID 244236842013[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)].Georgian medical news
- PMID 188300222008[The effect of heavy metal ions and peptide bioregulators on the expression of chromosome fragile sites in the individuals of different age groups and breast cancer patients].Georgian medical news
- PMID 174602032007Activation of pericentromeric and telomeric heterochromatin in cultured lymphocytes from old individuals. doi:10.1196/annals.1395.043Annals of the New York Academy of Sciences
- PMID 160756832005[Effect of peptide Livagen on activity of digestive enzymes in gastrointestinal tract and non-digestive organs in rats of different ages].Advances in gerontology = Uspekhi gerontologii
- PMID 150852532004Effects of short peptides on lymphocyte chromatin in senile subjects. doi:10.1023/b:bebm.0000024393.40560.05Bulletin of experimental biology and medicine
- PMID 129427482003[Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum].Izvestiia Akademii nauk. Seriia biologicheskaia
18 total in corpus · top 10 shown
Reviewed against the archive corpora on 2026-09-16. Source-grounded. No clinical claims. Synthesis prose may preserve published experimental context from papers; that is research history, not a recommendation.