A synthetic pineal tetrapeptide (AEDG) characterised from the Epithalamin fraction and widely discussed for telomerase and aging-related experimental work.
Bioregulator · Khavinson school · Ala-Glu-Asp-Gly (AEDG)
identity
sequence
Ala · Glu · Asp · Gly
codeAEDG|linebioregulator|schoolKhavinson
Archive sequence label. Residue order as used in this dossier. No clinical structure claim.
Key takeaways
Epitalon (AEDG; also epithalon / epithalon) is the synthetic tetrapeptide drawn from the pineal polypeptide fraction Epithalamin in the Khavinson bioregulator line.
Mapped papers cluster around telomerase-adjacent cell and oocyte work, pineal / melatonin / circadian frames, and immune-endocrine restore after pinealectomy. plus smaller ophthalmology and genotype-dependent antimutagenic series.
The densest mapped trail is St. Petersburg pineal-peptide literature from the Khavinson school. That corpus is this archive’s centre of gravity. This page is an archive map.
What it is
Epitalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly from the Khavinson pineal line. Sequence first characterised in the polypeptide fraction Epithalamin, then made chemically.
It is the best-known bioregulator on this shelf outside Russian specialist circles, largely because telomerase-activation language travelled with the sequence.
We feature it as the flagship pineal tetrapeptide in this archive’s bioregulator shelf.
What the literature describes
Themed chapters drawn only from papers already mapped on this dossier. Archive map. No medical advice.
Telomerase and aging-adjacent experimental frames
A 2025 PubMed overview summarises epitalon’s pineal-tetrapeptide experimental profile and the aging-adjacent claims discussed across the mapped corpus. Separate recent titles continue telomerase-linked experimental work, including non-human oocyte maturation and post-thaw embryo readouts.
These papers describe experimental systems and reported endpoints. This page grades none of them as clinical proof. Telomerase language is what attracts outside attention. Archive map only.
Pineal, melatonin, and circadian / endocrine framing
PubMed titles pair melatonin with epithalon / epitalon in models of premature reproductive aging, estrous-cycle disruption under varied lighting, and age-related thyrotrophic / thyroid dynamics. Related work discusses pineal peptides correcting impaired reproductive cycles in rats.
In vitro senescence work on human pineal and thymus cells reports AEDG (with KE) effects on mitochondrial staining and ribosomal-protein expression (cellular pineal-line texture; no human dosing study on this page).
Related Russian work discusses cytokine production by peripheral-blood cells under natural and synthetic peptides, and a pineal-peptide model of induced diabetes with pancreatic functional readouts. same pineal-line neighbourhood.
Drosophila selection-line papers discuss peptide effects on antioxidant status and survival curves; reading those toward human claims is outside this archive’s remit.
The corpus lives in the St. Petersburg Institute of Bioregulation and Gerontology pineal-peptide programme and closely adjacent Russian laboratories. Core mechanism and pineal-substitute papers are densest there; later titles also appear on PubMed.
Telomerase language travels farther than most bioregulators on this shelf. Still an archive map of what was written. No medical rating.
Open limits
How much of the mechanistic texture is single-school density versus multi-lab convergence inside the Russian pineal-peptide literature?
Which later titles on PubMed extend the originating circle’s protocols, and which open new experimental systems?
Effect-size language in older observational series is extraordinary on its face and is not treated as settled evidence on this page.
Russian full-text papers
Open-access Russian academic PDFs on CyberLeninka where we have them.
kompyuternoe modelirovanie vzaimodeystviya lizinovogo dendrimera i peptidov epitalonRussian full text
antimutagennye effekty sinteticheskogo peptida epitalona u myshey mus musculus razlichaRussian full text
molekulyarnye mehanizmy retinoprotektornogo deystviya korotkih peptidovRussian full text
vliyanie prirodnyh i sinteticheskih peptidov na produktsiyu tsitokinov kletkami periferRussian full text
kompensatornoe deystvie peptidov epifiza na organy immunnoy i endokrinnoy sistem u epifRussian full text
vliyanie peptidov na antioksidantnyy status i parametry krivyh vyzhivaniya selektiruemyRussian full text
peptid epifiza vosstanavlivaet funktsionalnuyu aktivnost podzheludochnoy zhelezy pri inRussian full text
lekarstvennye peptidnye preparaty proshloe nastoyaschee buduscheeRussian full text
bioaktivnye veschestva geroprotektornoy napravlennostiRussian full text
reversiya biologicheskogo vozrasta putem korrektsii tsirkadnyh ritmovRussian full text
2025Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. doi:10.3390/ijms26062691PubMed
2020[The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.].PubMed
2013[Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes].PubMed
2012Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats. doi:10.2174/1874609811205030003PubMed
2009[Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes].PubMed
2008Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments. doi:10.1007/s11055-008-0035-xPubMed
2008[Biological activity of regulatory peptides in model experiments in vitro].PubMed
Is AEDG the only active motif from epithalamin, or one of several?
What genetic difference underlies coat-colour-dependent antimutagenesis in mice?
Do retinoprotection mechanisms generalise across eye-disease models?
How should genotype-dependent Drosophila lifespan results be read for any human claim? Our map does not make that leap.
Reviewed against the archive corpora on 2026-09-19. Source-grounded. No clinical claims. Archive / history / research only. No medical advice. No dosing, synthesis, sourcing, or health claims.