A four-amino-acid peptide (Ala-Glu-Asp-Leu) developed for bronchial indications. One published paper (PMID 22117547) is mapped; no PubChem entry in our records. The trail sits in the Russian short-peptide bronchial series.
mechanism confidence: medium
Synthetic tetrapeptide Ala-Glu-Asp-Leu (AEDL). Havigan school lineage: AEDL was isolated from bronchial epithelium polypeptide fraction by chromatography-mass-spec, then synthesised. The molecular mechanism is well-characterised for this class: in human bronchial epithelial cell cultures, AEDL epigenetically regulates Ki67, Mcl-1, p53, CD79, NOS-3 protein synthesis (cell renewal) and activates differentiation genes Nkx2.1, SCGB1A1, SCGB3A2, FoxA1, FoxA2 plus mucin genes MUC4, MUC5AC, SftpA1. the exact set that goes down in chronic bronchitis. Bronchogen is effective and safe orally in chronic bronchitis remission patients, normalising pulmonary function indices. A ancillary finding: AEDL also protects tobacco callus from NaCl salinity at 10⁻⁷ M, comparable to plant-hormone-level potency.
- Human bronchial epithelial cell culture: AEDL upregulates Ki67/Mcl-1/p53/CD79/NOS-3 (cell renewal), activates Nkx2.1/SCGB1A1/SCGB3A2/FoxA1/FoxA2 (differentiation) and MUC4/MUC5AC/SftpA1 (mucins). Downregulation of these same genes correlates with chronic bronchitis development (Khavinson-Ryzhak-Linkova-Ashapkin-Drobinzeva-Basharina-Vanyushkin 2014)
- Chronic bronchitis patients in remission: oral AEDL normalises pulmonary function indices; safe (Khavinson 2014)
- Tobacco sprouts + callus under NaCl salinity: AEDL at 10⁻⁷ M enhances root/hypocotyl growth, reduces ROS, increases meristem + suction zone stress resistance; epidermal cells most protected; effects comparable to plant-hormone regulatory action (Kononenko 2018. mechanistic cross-kingdom finding)
- Khavinson 2020 master review: bronchogen is among the synthetic tetrapeptides (with Thymogen, Vilon, Pinealon, Vesugen, Epitalon, Cardiogen) that regulate gene expression, protein synthesis, chromatin state and telomerase elongation
grade: C-only (0 A / 0 B / 4 C). Gene/protein mechanism papers do not constitute clinical translation; Kononenko plant work is adjacent.
- Does the epigenetic regulation extend to human clinical settings beyond bronchial epithelium?
- Why does the peptide also work in plant tissue? Sequence-agnostic chromatin interaction, or genuine plant receptor orthologue?
- Telomerase activation claim (Khavinson 2020). is this direct or downstream of cell renewal?
- How should the mapped Russian clinical series in chronic bronchitis be read against the denser gene-regulation cell work?
- PMID 301992012017[ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY].Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
- PMID 264680222015Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology. doi:10.1007/s10517-015-3047-xBulletin of experimental biology and medicine
- PMID 212403582011Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability. doi:10.1007/s10517-011-1146-xBulletin of experimental biology and medicine
- PMID 171527282006[The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats].Advances in gerontology = Uspekhi gerontologii
- PMID 283716102017Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum. doi:10.1134/S0006297917040149Biochemistry. Biokhimiia
- PMID 228085152012Peptides tissue-specifically stimulate cell differentiation during their aging. doi:10.1007/s10517-012-1664-1Bulletin of experimental biology and medicine
6 total in corpus
Reviewed against the archive corpora on 2026-09-16. Source-grounded. No clinical claims. Synthesis prose may preserve published experimental context from papers; that is research history, not a recommendation.